Antiandrogens are used in the treatment of androgen-dependent skin and hair conditions including acne, seborrhea, hidradenitis suppurativa, hirsutism, and pattern hair loss in women.  All of these conditions are dependent on androgens, and for this reason, antiandrogens are effective in treating them.  The most commonly used antiandrogens for these indications are cyproterone acetate and spironolactone.  Flutamide has also been studied extensively for such uses, but has fallen out of favor due to its association with hepatotoxicity .  Bicalutamide, which has a relatively minimal risk of hepatotoxicity, has been evaluated for the treatment of hirsutism and found to be effective similarly to flutamide and may be used instead of it.   In addition to AR antagonists, oral contraceptives containing ethinylestradiol are effective in treating these conditions, and may be combined with AR antagonists.  
A nonsteroidal antiandrogen ( NSAA ) is an antiandrogen with a nonsteroidal chemical structure .   They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT).   NSAAs are used in the treatment of androgen-dependent conditions in men and women.  They are the converse of steroidal antiandrogens (SAAs), which are antiandrogens that are steroids and are structurally related to testosterone.