Nonsteroidal antiandrogen drugs

Antiandrogens are used in the treatment of androgen-dependent skin and hair conditions including acne, seborrhea, hidradenitis suppurativa, hirsutism, and pattern hair loss in women. [23] All of these conditions are dependent on androgens, and for this reason, antiandrogens are effective in treating them. [23] The most commonly used antiandrogens for these indications are cyproterone acetate and spironolactone. [63] Flutamide has also been studied extensively for such uses, but has fallen out of favor due to its association with hepatotoxicity . [64] Bicalutamide, which has a relatively minimal risk of hepatotoxicity, has been evaluated for the treatment of hirsutism and found to be effective similarly to flutamide and may be used instead of it. [65] [66] In addition to AR antagonists, oral contraceptives containing ethinylestradiol are effective in treating these conditions, and may be combined with AR antagonists. [67] [68]

A nonsteroidal antiandrogen ( NSAA ) is an antiandrogen with a nonsteroidal chemical structure . [1] [2] They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the effects of androgens like testosterone and dihydrotestosterone (DHT). [1] [2] NSAAs are used in the treatment of androgen-dependent conditions in men and women. [1] They are the converse of steroidal antiandrogens (SAAs), which are antiandrogens that are steroids and are structurally related to testosterone. [1] [2]

Nonsteroidal antiandrogen drugs

nonsteroidal antiandrogen drugs

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