Non steroidal oral contraceptives

Low-quality and conflicting evidence regarding the benefits of oral NSAIDs obtained from two trials could not be pooled. One trial found significantly greater improvement in pain compared with placebo , and the other trial found no between-group differences; neither trial found differences in function. One trial reported a withdrawal due to adverse effects for a participant in the NSAIDs group. Use of oral NSAIDs was associated with increased risk of gastrointestinal side effects compared with placebo in one trial in the review . Another trial reported discontinuation of treatment due to gastrointestinal side effects in four participants taking NSAIDs, and another participant developed an allergic reaction in response to oral NSAIDs.

Nueve estudios con 991 participantes compararon AINE con paracetamol. Aunque hay una tendencia a favor del paracetamol, no hubo diferencias clínicamente importantes entre los dos grupos en el dolor antes de las 24 horas (377 participantes, cuatro estudios; pruebas de calidad moderada), del primer al tercer día (431 participantes, cuatro estudios; baja calidad) y al séptimo día o después (467 participantes, cuatro estudios; baja calidad). Tampoco hubo diferencias entre los dos grupos en la inflamación al tercer día (86 participantes, un estudio; calidad muy baja) y al séptimo día o después (77 participantes, un estudio; baja calidad). Hubo una diferencia pequeña entre los dos grupos en el retorno a la función al séptimo día o después (316 participantes, tres estudios; muy baja calidad): según una recuperación de la función supuesta de 804 por 1000 participantes en el grupo de paracetamol, ocho menos por 1000 recuperados en el grupo de AINE (intervalo de confianza [IC] del 95%: 80 menos a 73 más). Hubo pruebas de calidad baja de un menor riesgo de eventos adversos gastrointestinales en el grupo de paracetamol: según un riesgo de eventos adversos gastrointestinales supuesto de 16 por 1000 participantes en el grupo de paracetamol, 13 participantes más por 1000 presentaron un evento adverso gastrointestinal en el grupo de AINE (IC del 95%: 0 a 35 más).

Four studies, involving 240 participants, compared NSAIDs with the combination of paracetamol and an opioid . The applicability of findings from these studies is partly in question because the dextropropoxyphene combination analgesic agents used are no longer in general use. While the point estimates favoured NSAID , the very low-quality evidence did not show a difference between the two interventions in the numbers with little or no pain at day 1 (51 participants, 1 study ), day 3 (149 participants, 2 studies), or day 7 (138 participants, 2 studies). Very low-quality evidence showed a similar lack of difference between the two groups applied to swelling at day 3 (reported in two studies) and at day 7 (reported in two studies), in return to function at day 7 (89 participants, 1 study ), and in gastrointestinal adverse events (141 participants, 3 studies).

Non steroidal oral contraceptives

non steroidal oral contraceptives

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