Steroids can worsen existing skin pathologies. Athletes being treated for acne often stop responding to normal treatment regimens if they also continue to use the drugs. Some cases of comparatively benign acne can progress to the disfiguring inflammatory types. Psoriasis is an autoimmune disease in which, for unknown reasons, immune cells attack skin cells, resulting in red, scaly patches. One bodybuilder had controlled his psoriasis condition through the use of a topical cream, but when he began using steroids, his condition considerably deteriorated. Eventually his psoriasis became resistant to treatment. But when he stopped using steroids, the psoriasis stabilized and again responded to simple skin-cream treatment. 6
There are come caveats associated with eccentric training. The extensive muscle fiber damage it produces leads to a few temporary metabolic derangements. For example, it inhibits the activity of a glucose carrier in muscle called GLUT-4, which delays the full recuperation of muscle because glycogen is not restored. Glycogen repletion is essential for full muscle recovery between workouts. In practical terms, it would be foolhardy to attempt to train any particular muscle again in less than 48 hours. If you truly emphasize negative work in your training, it will probably lengthen the required rest time between workouts to at least 72 hours. That may explain the recent trend of training most muscles groups only once a week. Many have found that more-frequent training leads to stalled progress and a feeling of overtraining, which may be related to incomplete repair of muscles that are trained too frequently.
The new study examined recent stretch marks and found that they had a higher density of hormone receptors than normal skin, and estrogen appeared to be the most concentrated. Since estrogen is involved in skin healing, that could represent the body’s attempt to heal the injured skin tissue. From the standpoint of steroid users, the greater number of estrogen receptors in stretch marks could also represent a defense against the high level of androgens, which interfere with skin healing. That latter part, however, is strictly speculation. What is known is that stretch marks have a higher density of hormone receptors than normal skin.