In case of suspected drug-induced gynecomastia, it would be opportune considering a therapy discontinuation. In some cases, it could be helpful reducing the doses or substituting the suspected drug with another one belonging to the same class, but with a weaker association to gynecomastia. 3
Mammography scan allows distinguishing with certainty between gynecomastia and pseudogynecomastia. On the other hand, laboratory tests are necessary for identifying other possible causes, checking the renal, hepatic and thyroid functions and the free-circulating hormones levels. 2
Iatrogenic gynecomastia is generally reversible within 6 months or one year since its onset. If drug discontinuation is not enough or not possible (for example with anti-androgens), a therapy based on tamoxifene (20 mg daily) might be taken into consideration. In fact, despite not being approved for this indication, literature data suggest a response rate of 50-80% of cases, with detectable improvements from the first month of treatment. 3 In the rare eventuality of both drug dechallenge and tamoxifene therapy being unsuccessful, it is possible to resort to surgery or radiotherapy, according to the patient’s needs.
Enlarged breasts on men can be an embarrassing issue. This issue can be caused by lifestyle factors as well as an hormonal imbalance in your body, a medical condition known as gynecomastia.  You can take practical steps to address this issue if you have enlarged breasts due to weight gain or gynecomastia. Work on managing your breast size by maintaining a healthy diet and doing exercises to strengthen your chest and burn body fat. If your enlarged breasts are caused by a hormonal imbalance, talk to your doctor about medical treatment options.