Brain sexual dimorphism can be established by neuronal migration, neurogenesis or apoptosis. The establishment of the SDN-POA has been attributed usually to apoptosis in females on postnatal days 8–10 ( 48 ). Testosterone ( 48 ) and oestradiol ( 49 ) prevent apoptosis during this period. We noted, however, that the number of somatostatin expressing cells in the rat SDN-POA increases continuously through postnatal days 1–15 in males or oestrogen-treated females, whereas the number remains unchanged in females or neonatally orchidectomised males ( 6 ). Interestingly, somatostatin expression in the SDN-POA diminished with a peak on day 14/15 in both sexes, whereas the sex difference detected by calbindin immunoreactivity in this particular structure was maintained after that date ( 18 ). We suggest, therefore, that a mechanism other than apoptosis is responsible for generating sexual dimorphism in the SDN-POA. We have identified differential regulation of Bax and Bcl2 genes by oestradiol between the AVPV and POA ( 50 ). Indeed, sex differences in Bax -null mice have been caused predominantly by apoptosis, albeit that these mice retain sexual dimorphism in the dopaminergic neurones of the AVPV, suggesting that different mechanisms operate in a site-specific manner ( 23 ). Our bromodeoxyuridine uptake study showed that neurones in the SDN-POA were born on embryonic day 16, and no new addition occurs during the later critical period (Orikosa C, Urakawa S, Sakuma Y, unpublished data). A contribution of migration in the formation of the SDN-POA was proposed, as shown by utilising a promoter transgenic rat that expresses enhanced green fluorescent protein in the SDN-POA under the control of ERα promoter 0/B ( 51 ).
Q. Had FMS for almost twenty years now, tried almost everything. Is Lyrica in the "steroid" family? Any one in this community could help me? I have given my few questions to find out an answer. I Had FMS for almost twenty years now, tried almost everything. I'm considering Lyrica but I'd like more info. Is Lyrica in the "steroid" family? If you go on Lyrica for a while & see no improvement with pain, is going off of it a big deal like with other med's, or can you simply just stop taking it? I take Ambien, will that have any interactions? I'm seeing my Doc about this at the end of the month, but I was hoping to get some personal experiences about it. Thanks for any thoughts! Thanks for your answers, keep them coming! A. according to this-
there is a moderate interaction. that means you can take them both but be checked regularly for depression of breath.