The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system. 
Soaps and wash products containing certain antibacterial ingredients can no longer be sold, the . The FDA cautions that widespread antiseptic use could be harmful over time, allowing bacteria to become more resistant. The report also cited potential hormonal effects from triclosan which is widely used as an antibacterial ingredient in household hand sterilization products that breaks down rapidly when exposed to chlorinated water and produces toxic chemicals including chloroform, according to a study published on the Environmental Science and Technology research website, suggesting that many antibacterial products may not only be ineffective, but harmful.
Pharmaceutical companies actually call the side effects "adverse reactions" on their "scare sheets". Contraindications are known preexisting conditions that might rule out the use of a particular drug. The list of adverse reactions and potential drug interactions is lengthy because every reaction during the testing trials is listed, whether known to be caused by the drug or not. Many of the reactions would have occurred regardless of the drug. This is a small but important point, and it shows the lack of any critical review taken in publishing this book. Each statement of a scientific basis for the claims calls for more skepticism.